We help clients align their quality systems with global requirements—evaluating compliance across international standards, national regulations, and region-specific expectations. Below is a breakdown of the primary frameworks and regulatory requirements our MDSAP and ISO audit services address. This is not an exhaustive list. Please talk to us for more details.
International Standards
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ISO 13485:2016 Quality management systems for medical devices. Audited in all MDSAP jurisdictions. Forms the foundation for quality system certification and regulatory alignment. Also relevant for the upcoming transition from the QSR to the QMSR in 2026.
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ISO 14971:2019 Risk management standard for medical devices. Often evaluated alongside ISO 13485 and required by multiple regulators.
Country-Specific Regulations Covered by MDSAP
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United States (FDA)
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21 CFR Part 820 – Quality System Regulation (QSR)
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21 CFR Part 803 – Medical Device Reporting
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21 CFR Part 806 – Reports of Corrections and Removals
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21 CFR Part 807 – Establishment Registration and Device Listing
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FDA's new Quality Management System Regulation (QMSR) alignment with ISO 13485
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Canada (Health Canada)
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Medical Devices Regulations (SOR/98-282)
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Licensing and mandatory problem reporting requirements
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Emphasis on ISO 13485:2016 compliance via MDSAP participation
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Brazil (ANVISA)
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RDC No. 665/2022 – Brazilian Good Manufacturing Practices (BGMP)
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RDC No. 751/2022 – Risk classification and regularization
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Additional documentation, language, and legal representation requirements
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Japan (MHLW/PMDA)
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Ministerial Ordinance No. 169 – Quality Management System requirements
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GVP Ordinance – Good Vigilance Practices
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GCP Ordinance – Good Clinical Practices (when applicable)
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Australia (TGA)
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Therapeutic Goods (Medical Devices) Regulations
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TGA Conformity Assessment Procedures
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Essential Principles aligned with ISO 13485 and risk-based classification
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